Tammy (Melissa McCarthy) is having a bad day. She’s written off her car, been fired from her thankless job at a greasy burger joint, and instead of finding comfort at home, finds her husband getting comfortable with the neighbour in her own house. It’s time to take hit the road and start anew. The bad news is she’s broke and without wheels. However, she soon learns that her grandma, Pearl (Susan Sarandon) has a car, cash, and an itch to see Niagara Falls. Maybe a road trip, with grandma riding shotgun, may be just what Tammy needs.